Category: 85064-61-5

85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1: N-[6-(4-Morpholinyl)-3-pyridinyl]-2-(tetrahydro-2H-pyran-4-yl)-N-[(1-(at)[4- (trifluoromethyl)phenyl]methyl)-4-piperidinyl)methyl]acetamide; Oxalyl chloride (0.27ml, 3.05mmol) was added to a stirred solution of tetrahydro-2H- pyran-4-ylacetic acid (0.2g, 1.38mmol) in DCM (10ml). DMF (1 drop) was added and the reaction mixture stirred at room temperature for 1.5h then evaporated in vacuo to afford a colourless oil (1.17g). The crude acid chloride was dissolved in DCM (10ml) and added to a stirred solution of 6-(4-morpholinyl)-N-[(1-{[4-(trifluoromethyl)phenyl]methyl)-4- piperidinyl) methyl]-3-pyridinamine D5 (0.45g, 1.03mmol) and triethylamine (0.58ml, 4.12mmol) in DCM (10ml). After 24h the mixture was washed with saturated sodium hydrogen carbonate, the organic layer separated by passage through a phase separation cartridge and evaporated in vacuo. Chromatography on silica gel eluting with 50-100% ethyl acetate in pentane gradient afforded the title compound as an orange gum (0.47g). A 70mg portion was dissolved in 1:1 DMSO/MeCN (0.9ml) and purified by mass directed autoprep hplc on a Waters C18 5muM column 8(id 19 x 100mm) eluting with 5 – 99% MeCN in water gradient containing 0.1 % formic acid. Fractions containing the desired material were passed through a 2g SCX column, the column washed with methanol (30ml) and eluted with 1 N ammonia in methanol to afford the title compound as a colourless gum (0.05g). Mass Spectrum (AP+): Found 561 (MH+). C30H39F3N403 requires 560.

The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/103038; (2005); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Triethylamine (14.84 mmol) was added to a solution of the carboxylic acid (7.42 mmol) in THF (31.0 mL, 0.2 M) at room temperature, stirred for 10 min, and then cooled to 0 C before addition of pivaloyl chloride (8.90 mmol). After 30 min at 0 C, lithium chloride (0.5 M in THF, 8.90 mmol) was added, followed by (R)-(+)- or (S)-(-)-4-benzyloxazolidin-2-one (8.90 mmol) and the mixture was stirred at room temperature for 20 h. The mixture was partitioned with EtOAc (20 mL) and 1M HCl (3*20 mL) and the organic layer was washed with 1M K2CO3 (3*20mL). The acidic aqueous layer was extracted with EtOAc (20 mL) and the combined organic layer was washed with brine (10 mL), dried (MgSO4), filtered, and concentrated under vacuum. The crude material was purified as indicated.

The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shouksmith, Andrew E.; Evans, Laura E.; Tweddle, Deborah A.; Miller, Duncan C.; Willmore, Elaine; Newell, David R.; Golding, Bernard T.; Griffin, Roger J.; Australian Journal of Chemistry; vol. 68; 4; (2015); p. 660 – 679;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics