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Aryl substituted amino hydrogen pyrane class compound and use thereof (by machine translation)

The invention relates to an aryl substituted amino hydrogen pyrane class compounds and their use, further relates to the pharmaceutical composition. The compound of the invention or the pharmaceutical composition can be used as dipeptidyl peptidase – IV (DPP – IV) inhibitors. (by machine translation)

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Reference:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Patent£¬once mentioned of 951127-25-6, Recommanded Product: tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate

The invention relates to a six-member ring amino derivatives and its application in medicine, specifically relates to the general formula (I) as shown by the six-member ring of the amino derivative or its stereoisomer, pharmaceutically acceptable salt, prodrug, pharmaceutical composition containing the derivative of the dipeptidyl peptidase IV and the preparation (dPP CGI-iV) inhibitors of their medical use, wherein the general formula (I) definition of each substituent in the definition of the description of the same. (by machine translation)

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Patent£¬once mentioned of 951127-25-6, Computed Properties of C16H19F2NO4

The invention relates to a pyrrolo imidazole ring derivative and its application in medicine, specifically about the general formula (I) indicated by the pyrrole and imidazole ring derivative or a stereoisomer thereof, a pharmaceutically acceptable salt, prodrug, a pharmaceutical composition containing the derivative of the dipeptidyl peptidase IV and the preparation (dPP CGI-iV) inhibitors of their medical use, wherein the general formula (I) definition of each substituent in the definition of the description of the same. (by machine translation)

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C16H19F2NO4. In my other articles, you can also check out more blogs about 951127-25-6

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a Patent£¬once mentioned of 951127-25-6, Formula: C16H19F2NO4

Shown in vitro and in vivo experimental verification, of the benzoditetrahydropyrrole compound disclosed by the invention has a very good selectivity inhibiting effect I in vitro and in vivo experimental verification, and the method is expected to achieve relatively low toxicity of, and, after development of the compound of the present invention. DPP – IV. The compound of the present invention is expected to have relatively low toxicity compared with oral one-time pharmaceutical oxagliptin in a long time after being developed by the compound of Formula, below DPP – IV active inhibition rate of, The present invention is expected to provide a therapeutically effective amount of a benzoditetrahydropyrrole compound according to the present invention and a pharmaceutically acceptable salt DPP – VIII in vitro and in vivo experimental verification of DPP – IX ?, mg of orally administered pharmaceutical oxalogliptin for a long time after, the development of the compound of the present invention in vitro and in vivo results . shown in, Table. for industrial . mass production, of the present invention. (by machine translation)

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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Novel potent and selective 5,6,5- and 5,5,6-tricyclic pyrrolidine dipeptidyl peptidase IV (DPP-4) inhibitors were identified. Structure-activity relationship (SAR) efforts focused on improving the intrinsic DPP-4 inhibition potency, increasing protease selectivity, and demonstrating clean ion channel and cytochrome P450 profiles while trying to achieve a pharmacokinetic profile suitable for once weekly dosing in humans.

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Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The important role of tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate

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Amino pyran ring derivatives and compositions and uses thereof (by machine translation)

The invention relates to amino-pyran ring derivatives and compositions and uses thereof, in particular with regard to the general formula (I) indicated by the amino pyran ring derivative or a stereoisomer thereof, a pharmaceutically acceptable salt, prodrug, a pharmaceutical composition containing the derivative of the dipeptidyl peptidase IV and the preparation (dPP CGI-iV) inhibitors of their medical use, wherein the general formula (I) definition of each substituent in the definition of the description of the same. (by machine translation)

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

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PYRROLIDINONE COMPOUNDS

The present invention provides a compound which is of formula (II), wherein X is selected from the group consisting of (X) or a pharmaceutically acceptable salt thereof, methods for treating obesity, providing therapeutic weight loss, and compositions.

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Tetrahydropyran – Wikipedia,
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TRICYCLIC HETEROAROMATIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel substituted tricyclic heteroaromatic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

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Reference£º
Tetrahydropyran – Wikipedia,
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As inhibitors of dipeptidyl peptidase-IV derivatives Aminotetrahydropyrans (by machine translation)

The invention provides general formula (I) of such derivatives Aminotetrahydropyrans, its pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, and a process for their preparation and a pharmaceutical composition of the compound. The compounds can inhibit the activity of the dipeptidyl peptidase IV(DPP-IV), can be used in the treatment of diseases related to dipeptidyl peptidase IV. (by machine translation)

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics