Category: 951127-25-6

Synthetic Route of 951127-25-6. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate. In a document type is Patent, introducing its new discovery.

PROCESS FOR PREPARING 2, 3-DISUBSTITUTED-5-OXOPYRAN COMPOUND

A process of preparing 2, 3-disubstituted-5-oxopyran compounds, comprising cyclizing a compound in the presence of a base and an organic solvent is provided.

If you are interested in 951127-25-6, you can contact me at any time and look forward to more communication.Synthetic Route of 951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate. In a document type is Patent, introducing its new discovery.

PROCESS FOR PREPARING 2, 3-DISUBSTITUTED-5-OXOPYRAN COMPOUND

A process of preparing 2, 3-disubstituted-5-oxopyran compounds, comprising cyclizing a compound in the presence of a base and an organic solvent is provided.

If you are interested in 951127-25-6, you can contact me at any time and look forward to more communication.951127-25-6

Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,951127-25-6

2.46 kg of Compound III and 3.12 kg of Compound II were added to 15 L of N, N-dimethylacetamide, and nitrogenUnder guard,Circulating frozen saline bath to 5 ¡À 5 ,Added dropwise trimethyl orthoformate 2.2Kg,Sodium borohydride acetate was added in portions3.19Kg,Stirred at 5 ¡À 5 C for 2 hours,Heated to 50 ¡À 5 for about 10 hours;Circulating frozen saline bath to 5 ¡À 5 ,45 C below the drop in water 15L,Add Bi temperature at this temperature for 1 hour,Heated to 50 ¡À 5 C for 2 hours,Centrifuge,Wet product washed with water 5L three times,Wet product was added to the water 15L beating 1 hour,Centrifuge,50 C for 12 hours under vacuum.Get gray whiteSolid was added isopropyl ether 12L,Heated to 60 ¡À 5 ,Then add n-heptane 12L, cooled to 15 ¡À 5 , incubated for 1 hour,Suction filtered and dried under vacuum at 40 C for 12 hours to obtain 3.1Kg of white solid with a yield of 82.5%

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; Shanghai Bozhi Yan Xin Pharmaceutical Co., Ltd.; Ying Shuhuan; Pi Hongjun; Chen Jian; (14 pag.)CN106674227; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

951127-25-6, tert-Butyl N-[(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydropyran-3-yl]carboxylate(0.22 g, 0.67 mmol) was dissolved in N,N-dimethylacetamide (3.3 mL).Add 2-(2-thienylsulfonyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole 4-methylbenzenesulfonate (0.38 g, 0.89 mmol) at room temperature 10 minutes, nitrogen protection,Sodium triacetoxyborohydride (0.83 g, 3.93 mmol) was slowly added at 0 C.The reaction was resumed at room temperature for 12 hours.The reaction was quenched by the addition of aqueous ammonia/water (v/v = 2/3, 50 mL) and filtered.The obtained solid was purified by silica gel column chromatography [methanol / dichloromethane (v / v) = 1 / 9]The title compound was obtained (0.30 g, yield 79%).It is a brown foamy solid.

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Li Jianhao; Gu Zheng; Deng Xinshan; Tang Wanjun; Zhang Zongyuan; Kang Panpan; Yuan Weihui; Peng Fei; (49 pag.)CN109942583; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At room temperature,2a (0.350 g, 1.14 mmol) was dissolved in N, N-dimethylacetamide (4 mL), intermediate 1 (0.338 g, 1.04 mmol) was added and stirred at 0 C for 1 hour. Sodium tris (acetoxy) borohydride (0.285 g, 1.34 mmol) was added to the reaction solution and allowed to warm to room temperature for 16 hours. The reaction solution was cooled to C, water was added in that order, and the pH was adjusted to 8 with ammonia to precipitate a white solid. The reaction solution was filtered and the filter cake was washed successively with water (5 mL x 3), petroleum ether (10 mL x 1). The filter cake was dried to give a white solid 2b (0.230 g, yield 48.4%)., 951127-25-6

As the paragraph descriping shows that 951127-25-6 is playing an increasingly important role.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; FAN, JIANG; FENG, JIAN-CHUAN; PENG, FEI; CHEN, QING-PING; (89 pag.)TW2017/8224; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,951127-25-6

At room temperature, 32e (0.338 g, 0.88 mmol) was dissolved in N, N-dimethylacetamide (6 mL) at room temperature, Intermediate 1 (0.317 g, 0.97 mmol) was added and the mixture was stirred at room temperature for 60 minutes. A solution of sodium tris(acetoxy)borohydride (0.371 g, 1.76 mmol) was added to the reaction solution at 0 C, and the mixture was gradually added to the reaction at room temperature for 3 hours. The reaction solution was cooled to 0 C, adjusted to pH 8 with water (20 mL) and aqueous ammonia (10 mL), extracted with dichloromethane (50 mL x 3). The organic phases were combined and washed with saturated brine solution (50 mL x 1) Dried over anhydrous magnesium sulfate, filtered, the filtrate was spin dried, and the column chromatography (dichloromethane / methanol (v / v) = 40: 1)A yellow solid 32f (0.292 g, yield 61%) was obtained.

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

951127-25-6, At room temperature, 6a(0.327 g, 1.10 mmol) was dissolved in Nu, Nu-dimethylacetamide(4 mL) was added intermediate 1 (0.356 g, 1.10 mmol) and stirred at 0 C for 1 hour. Sodium tris (acetoxy) borohydride (0.303 g, 1.43 mmol) was added to the reaction solution and allowed to warm to room temperature for 16 hours. The reaction solution was cooled to C, followed by adding water and aqueous ammonia to adjust the pH to 8 to precipitate a white solid. The filter cake was washed successively with water (5 mL chi 3) and petroleum ether (10 mL chi 1). The residue was dried and the cake was dried to give a white solid 6b (0.367 g, 63.7% yield).

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; FAN, JIANG; FENG, JIAN-CHUAN; PENG, FEI; CHEN, QING-PING; (89 pag.)TW2017/8224; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

55c (1.09 g, 1.78 mmol) was dissolved in N, N-dimethylacetamide (15 mL)Intermediate 1 (0.64 g, 1.95 mmol) was added to the reaction system at room temperature for 30 minutes. The reaction system was cooled to 0 C and sodium borohydrogen triacetate (0.65 g, 3.47 mmol) was added. The reaction was continued for 30 minutes and the reaction was continued at room temperature for 2 hours. The reaction solution was cooled to 0 C, water (40 mL) was added in that order, aqueous ammonia (5 mL) was added to adjust the pH to 9, and the solid was washed with water (50 mL x 3). The solid compound was dissolved in dichloromethane and treated with dichloromethane ¡Á 3), the organic phase was combined, washed with saturated brine solution (50 mL x 1), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated and purified by column chromatography (dichloromethane / methanol (v / v) = 20 : 1) to give a yellow solid 55d (0.68 g, yield 70%)., 951127-25-6

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

951127-25-6, Compound 3(200 mg, 0.611 mmol) and HSCH2CH2SH (0.11 mL, 1.53 mmol) were dissolved in DCM (10 mL) and treated with BF3 etherate (0.077 mL, 0.611 mmol) at RT. The resulting solution was stirred at RT for 1 h, and quenched with sat. aq. NaHCO3 solution. The organic phase was separated andextracted with DCM for several times. Combined organic phases were dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography (SiO2, 60 – 90 oC PE:EtOAc =10:1) to yield the product 8 (white solid, 212 mg, 0.525 mmol, 86%). M.p. 156.6 – 159.0 (dichloromethane); Rf 0.2 (10 : 1, petroleum ether : EtOAc); [alpha]D -7.88 (c 0.165, CHCl3) ; HPLC tR 3.6min; 1H NMR (600 MHz, CDCl3) delta 7.28 (s, 1H, ArH), 6.95 (s, 2H, ArH), 4.45 (d, J = 9.0 Hz, 1H, NHBoc),4.42 (d, J = 9.9 Hz, 1H, H-1), 4.00 (dd, J = 12.0 Hz, 1.8 Hz, 1H, H-5), 3.86 (d, J = 9.0 Hz, 1H, H-2), 3.74(d, J = 11.6 Hz, 1H, H-5?), 3.34 (ddd, J = 22.8, 12.0, 5.8 Hz, 4H, Dithiolane-CH2), 2.63 (d, J = 12.9 Hz, 1H,H-3), 2.19 – 2.01 (m, 1H, H-3?), 1.27 (s, 9H, C(CH3)3); 13C NMR (151 MHz, CDCl3) delta 159.10 (d, J C-F =243.0 Hz, ArC), 156.29 (d, J C-F = 240.6 Hz, ArC), 154.55 (C=O), 128.00 (dd, J C-C-F = 15.5, 7.9 Hz, ArC),116.40 – 116.13 (m, ArC), 116.13 – 115.81 (m, ArC), 115.34 – 115.07 (m, ArC), 79.75 (C(CH3)3), 77.84(C-5), 76.01 (C-1), 64.88 (C-4), 52.80 (C-2), 46.52 (C-3), 38.96 (Dithiolane-CH2), 38.78(Dithiolane-CH2), 28.24 (C(CH3)3); HRMS (ESI+) calcd. For C18H23F2NNaO3S2+426.0980, found426.0968.

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, You; Liu, Tongchao; Li, Chungang; Xiong, Bing; Zhao, Dongmei; Cheng, Maosheng; Chen, Guohua; Shen, Jingkang; Chen, Yue-Lei; Synthetic Communications; vol. 47; 4; (2017); p. 357 – 363;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15a (342 mg, 0.656 mmol) and Intermediate 1 (236 mg, 0.722 mmol) were dissolved in N, N-dimethylacetamide (5 mL) and stirred at room temperature for 0.5 hour, A solution of sodium tris (acetoxy) borohydride (375.3 mg, 1.771 mmoL) was added to the ice bath,Stir at room temperature for 2 hours. To the reaction solution was added concentrated aqueous ammonia (10 mL) and saturated sodium chloride solution (30 mL)And the mixture was stirred for 0.5 hour. The filtrate was extracted with dichloromethane (30 mL x 3). The filter cake was dissolved with the combined organic phase, dried over anhydrous sodium sulfate, filtered and dried by rotary separation. The residue was purified by silica gel column chromatography (Dichloromethane / methanol (v / v) = 30: 1 to 20: 1, a small amount of aqueous ammonia was added) to give a yellow solid as a yellow solid 15b (200 mg, yield 59%).

951127-25-6, The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics