Category: 951127-25-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

To a solution of 5-bromoisoindoline hydrochloride (3.00 g, 12.5 mmol) and tert- butyl N-[(2R,3S)-2-(2,5-difluorophenyl)-5-oxo-tetrahydropyran-3-yl]carbamate (4.14 g, 12.7 mmol) in DMAc (120 mL) is added triethylamine (3.5 mL, 25.1 mmol). The resulting mixture is stirred at 10 C for 15 minutes. Then HO Ac (2.26 g, 37.6 mmol) is added and the mixture is stirred for 1 hour. Sodium triacetoxyborohydride (10.6 g, 50.1 mmol) is added to the solution at 0 C. The resulting mixture is stirred at 10 C for 16 hours. The pH of the reaction mixture is adjusted to 5-6 with 1 M HCl aqueous solution. The resulting solution is diluted with water (800 mL) and extracted with EtOAc (3 x300 mL). The combined organic extracts are washed with brine (3 x500 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product is purified by silica gel flash chromatography eluting with DCM : MeOH (50: 1) to give the title compound (5.50 g, 84.4%) as a brown solid. ES/MS (m/z) (79Br/81Br) 511.4/513.4 [M +H].

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD; HO, Koc Kan; QUAN, Weiguo; ZHOU, Jingye; (51 pag.)WO2018/102256; (2018); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70 f (1.78 g, 3.2 mmol) was dissolved in N,N-dimethylacetamide (10 mL)Intermediate 1 (1.15 g, 3.52 mmol) was added and reacted at room temperature for 30 min.The reaction system was cooled to 0 C, Sodium borohydrophosphate (1.37 g, 6.24 mmol) was added, reacted for 30 minutes, The reaction was continued at room temperature for 2 hours. The reaction solution was cooled to 0 C, water (40 mL) was added in that order, aqueous ammonia (5 mL) was added to adjust the pH to 9, and the solid was washed with water (50 mL x 3). The solid was dissolved in dichloromethane, dichloromethane ), The organic phase was combined, washed with saturated brine solution (50 mL), dried over anhydrous sodium sulfate, filtered, the filtrate was concentrated, and purified by silica gel column chromatography (dichloromethane / methanol (v / v) = 20: 1) ,A 70 g (1.15 g, yield 85%) of a white solid was obtained.

The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics