116131-44-3, 3-(Bromomethyl)tetrahydro-2H-pyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[00176] To a solution of 2 (100 mg, 0.452 mmol) in dry DMF (3 mL) was added NaH (60%, 27 mg, 0.678 mmol) in several portions under ice-water bath. Then the mixture was stirred at rt for 10 min and followed by addition of 15.2 (138 mg, 0.768 mmol) and then it was stirred at 50 C overnight. The mixture was diluted with water and extracted with EA for 3 times. The organic layer was combined and washed with brine for 3 times, dried over Na2S04, concentrated and then purified by prep-TLC (eluent: PE~PE/EA=2:1 ) to give the title compound (1 10 mg, 76%) as a yellow oil. 1H NMR (300 MHz, DMSO-cf6) delta ppm 7.99 (s, 1 H), 7.91 (s, 1 H), 7.87 (d, 1 H), 7.66 (d, 1 H), 4.22 (m, 2H), 3.74 (d, 1 H), 3.66 – 3.61 (m, 1 H), 3.35 (s, 1 H), 3.26 – 3.15 (m, 1 H), 2.11 (s, 1 H), 1 .64 (s, 2H), 1 .52 – 1 .39 (m, 1 H), 1 .38 – 1 .22 (m, 1 H). LC-MS: [M+H]+ = 318.92, 320.87.
116131-44-3 3-(Bromomethyl)tetrahydro-2H-pyran 22617257, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; NOVARTIS AG; HE, Feng; DU-CUNY, Lei; XIAO, Qitao; XUN, Guoliang; ZHENG, Qiangang; (152 pag.)WO2017/149463; (2017); A1;,
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