Tag: 125552-89-8

125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-oxo-5- (p-tolyl) -1,4-dihydropyridazine-3-carboxylic acid ethyl ester hydrochloride (4.2 g, 14.3 mmol, 1.0 eq) was dissolved in DMF (30 mL), Potassium carbonate (7.88 g, 57.2 mmol, 4.0 eq) and 4- (bromomethyl) tetrahydro-2H-pyran (3.06 g, 17.1 mmol, 1.2 eq) were added, and the reaction was heated to 50 C with stirring for 5 hours. The reaction was detected by LC-MS. The insoluble matter was removed by suction filtration. The filtrate was concentrated.The crude product was purified by silica gel column chromatography (100-200 mesh silica gel, EA / PE = 10-50%), and then recrystallized with a mixed solvent of DCM and MTBE (1:10) to obtain the product (1.6 g, yield: 32% ).

125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Wan Zhonghui; (107 pag.)CN110041316; (2019); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

125552-89-8, 4-(Bromomethyl)tetrahydropyran is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the stirred solution of lH-indole-2-carbaldehyde (1, 1.0 g, 6.89 mmol) in N, N-dimethylformamide (10 mL), cesium carbonate (6.70 g, 20.68 mmol) and 4- (bromomethyl)tetrahydro-2H-pyran (1.48 g, 8.27 mmol) were added at room temperature. The reaction mixture was stirred at room temperature for 1 h. After completion of reaction, reaction mixture was diluted with water and extracted with ethyl acetate (200 mL x 2). The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude was purified by CombiFlash using 12 g RediSep and 5% ethyl acetate in hexane as eluent to afford l-((tetrahydro-2H-pyran-4-yl)methyl)-lH-indole-2-carbaldehyde as white solid). Yield: 0.80 g (48%). MS (ESI);243.13 m/z found: 244.17[M+H]+1.

125552-89-8 4-(Bromomethyl)tetrahydropyran 2773286, aTetrahydropyrans compound, is more and more widely used in various.

Reference£º
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; (247 pag.)WO2019/58393; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics