Tag: M.W:300-400

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

In a 500mL reaction flask, add intermediate V4 (24.5g, 32mmol, 1.0eq), intermediate VM4 (13g, 41mmol, 1.3eq) and 800mL dichloromethane, stir to dissolve, then add CDI (7.7g, 48mmol, 1.5eq ) And 2.5g DMAP, heated to 30-35 reaction,TLC monitors the reaction.After the reaction is completed, add 300mL of 10% acetic acid aqueous solution and stir for 30min to separate the organic phase.The organic phase was washed with saturated aqueous sodium bicarbonate solution (200 mL ¡Á 1) and saturated aqueous sodium chloride solution (200 mL ¡Á 1), dried over anhydrous sodium sulfate, filtered with suction, and the filtrate was concentrated under reduced pressure to obtain a crude solid product. The crude product was recrystallized with 300 mL of ethyl acetate and n-hexane (1: 1),29.2 g of solid product V5 was obtained.Yield: 87%.

1228779-96-1, As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

Reference£º
Patent; Nantong Changyou Pharmaceutical Technology Co., Ltd.; Li Zebiao; Chen Dan; Wu Hongdang; Xu Xiaohong; Lin Yanfeng; (9 pag.)CN110878098; (2020); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2 – ((1 H-pyrrolo [2,3 -b] pyridin-5- yl) oxy) -4- 5,Tetrahydro- [1,1′-biphenyl] -2-yl) methoxy) azetidin- 1 -yl) benzoic acid (50 mg, 0.089 mmol, 1.0 eq) and3-nitro-4-(((Tetrahydro-2H-pyran-4- yl) methyl) amino) benzenesulfonamide (31 mg, 0.098 mmol, 1.1 eq)8 mL of DCM, EDCI (34 mg, 0.18 mmol, 2.0 eq) and DMAP (13 mg, 0.107 mmol, 1.2 eq)at rt 7h. The reaction was stopped, poured into water and the organic phase was separated. The organic phase was dried over anhydrous sodium sulfate, spun dry and passed through a plug of PE / EA (v / v) =1/1 do eluent to obtain 35mg yellow powder product., 1228779-96-1

As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

Reference£º
Patent; Sun Yat-sen University; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Kou Yuhui; Hu Bolin; Jiang Haigang; Ye Jiuyong; Liu Zhiqiang; Xie Hongming; Zhang Yingjun; Yan Ming; (39 pag.)CN106749233; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

83-87-4, (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

83-87-4, (1) Weigh the hydroxyacetylated glucose intermediate (35 g, 89.7 mmol) obtained in step (1)Triethylamine (4.75 g, 46.9 mmol),3,4-dimethoxyphenol (20G, 129.7 mmol),Sequentially added to dichloromethane (250mL) at 0 C conditions,Boron trifluoride ethyl ether silica gel (50 g)Then naturally warmed to room temperature for 9 hours; then the organic phaseWashed successively with saturated sodium bicarbonate, saturated brine, filtered,Concentrated, recrystallized from anhydrous methanol,A yield of 94.3% was obtained for 40.95 g of glycoside intermediate substituted at the position of glucose anomeric carbon.

As the paragraph descriping shows that 83-87-4 is playing an increasingly important role.

Reference£º
Patent; Dongying Daoyi Bio-pharmaceutical Technology Co., Ltd.; Weifang Hongnuo He Tai New Materials Technology Co., Ltd.; Li Fahui; (5 pag.)CN107151260; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.

A mixture of2-((1 H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1 -yl)benzoic acid (1.75 g, 3 mmol), 3-nitro-4- (((tetrahydro-2H-pyran-4-yl)methyl)am ino)benzenesulfonam ide (1.43 g, 4.5) reacted in EDCI (1.15 g, 6 mmol) and 4-(N,N-dimethylamino)pyridine (550 mg, 4.5 mmol) and dichloromethane (40 ml) at room temperature overnight, and then water was added. The aqueous[2,3-b]pyridin-5-yl)oxy)-4- (4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1 -yl)-N-((3-nitr o-4-((tetrahydro-2H-pyran-4-yl)methyl)am ino)phenyl)sulfonyl)benzam ide (1.7 g, 64.4%) was obtained as a yellow solid.1H NMR (400 MHz, methanol-d4) O 8.70 (d, J = 2.3 Hz,1 H), 8.01 (d, J =2.7 Hz, 1 H), 7.87 (d, J = 9.2, 2.3 Hz, 1 H), 7.66 (d, J = 8.9 Hz, 1 H),7.55 (d, J =2.7 Hz, 1H), 7.47 (d, J = 3.4 Hz, 1H), 7.38 (d, J = 8.4 Hz, 2H), 7.10 (d, J =8.4Hz, 2H), 6.97 (d, J = 9.2 Hz, 1 H), 6.77 (dd, J = 8.9, 2.4 Hz, 1 H), 6.44 (d, J =3.4Hz, 1 H), 6.34 (d, J = 2.4 Hz, 1 H), 4.02 – 3.94 (m, 3H), 3.66 (5, 3H), 3.49 -3.38 (m,2H), 3.41 – 3.25 (m, 7H), 2.42 (5, 3H), 2.26 (5, 3H), 2.00 – 1.67 (m, 4H),1.45- 1.38(m, 2H)., 1228779-96-1

1228779-96-1 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide 57474953, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENTAGE PHARMA (SUZHOU) CO., LTD.; YANG, Dajun; ZHAI, Yifan; WANG, Guangfeng; (88 pag.)WO2020/24826; (2020); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,951127-25-6

At room temperature, 32e (0.338 g, 0.88 mmol) was dissolved in N, N-dimethylacetamide (6 mL) at room temperature, Intermediate 1 (0.317 g, 0.97 mmol) was added and the mixture was stirred at room temperature for 60 minutes. A solution of sodium tris(acetoxy)borohydride (0.371 g, 1.76 mmol) was added to the reaction solution at 0 C, and the mixture was gradually added to the reaction at room temperature for 3 hours. The reaction solution was cooled to 0 C, adjusted to pH 8 with water (20 mL) and aqueous ammonia (10 mL), extracted with dichloromethane (50 mL x 3). The organic phases were combined and washed with saturated brine solution (50 mL x 1) Dried over anhydrous magnesium sulfate, filtered, the filtrate was spin dried, and the column chromatography (dichloromethane / methanol (v / v) = 40: 1)A yellow solid 32f (0.292 g, yield 61%) was obtained.

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83-87-4,(3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate,as a common compound, the synthetic route is as follows.

83-87-4, To a solution of 30.0 g (76.8 mmol, 1 eq.) penta-O-acetyl-alpha/beta-D-glucopyranose (1) cooled to 0 C in 150 mL abs. dichloromethane 15.2 g (122 mmol, 1.6 eq.) thiocresol and 14.0 mL BF3Et2O (100 mmol, 1.3 eq.) were added slowly. After the addition, the solution was allowed to warm to room temperature and was stirred 24h. The organic phase was neutralized with sat.aq. NaHCO3 (3 ¡Á 70 mL), water (2 ¡Á 70 mL) and brine (50 mL). The organic layer was dried with MgSO4, filtered and the solvent was removed under reduced pressure. The crude product was purified by flash chromatography on silica (cHex/EtOAc, 2:1).

83-87-4 (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate 10293747, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Johannes, Manuel; Reindl, Maximilian; Gerlitzki, Bastian; Schmitt, Edgar; Hoffmann-Roeder, Anja; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 155 – 161;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

951127-25-6, At room temperature, 6a(0.327 g, 1.10 mmol) was dissolved in Nu, Nu-dimethylacetamide(4 mL) was added intermediate 1 (0.356 g, 1.10 mmol) and stirred at 0 C for 1 hour. Sodium tris (acetoxy) borohydride (0.303 g, 1.43 mmol) was added to the reaction solution and allowed to warm to room temperature for 16 hours. The reaction solution was cooled to C, followed by adding water and aqueous ammonia to adjust the pH to 8 to precipitate a white solid. The filter cake was washed successively with water (5 mL chi 3) and petroleum ether (10 mL chi 1). The residue was dried and the cake was dried to give a white solid 6b (0.367 g, 63.7% yield).

951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; FAN, JIANG; FENG, JIAN-CHUAN; PENG, FEI; CHEN, QING-PING; (89 pag.)TW2017/8224; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

83-87-4, (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of peracetylated or perbenzoylated sugars (300 mg) in 4 mL ofdry DCM at room temperature, TMSN3 (3 equiv) was added followed by the addition of AuBr3 (amounts of the catalyst are given in Table 1 and Table 2). The reaction mixture was stirred either at room temperature or heated to 55-60 C as mentioned in the Table 1 and Table 2. Then, the reaction was quenched byadding triethylamine (20 muL). The mixture was concentrated in vacuo and the crude product was purified by column chromatography.Alternatively, the reaction can be quenched by adding sodium bicarbonate solution followed by extraction with DCM(2 ¡Á 20 mL). The combined organic layers were washed with water, brine and dried over Na2SO4 and concentrated to dryness. The residue was purified by column chromatography on silica gel using petroleum ether (bp 60-70 C) and EtOAc., 83-87-4

83-87-4 (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate 10293747, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Rajput, Jayashree; Hotha, Srinivas; Vangala, Madhuri; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 682 – 687;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

83-87-4,83-87-4, (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,2,3,4,6-penta-O-acetyl-D-glucopyranose (1.678g, 4.30mmol) dissolved in DCM (10.75mL) was added hydrogen bromide (33% in acetic acid, 2.97mL) dropwise at 0C. The reaction mixture was then allowed to warm to room temperature and stir for an additional 4h. The reaction was quenched with water and the aqueous layer was extracted with DCM. The organic layers were combined and washed with water, saturated aqueous NaHCO3, brine, and then dried with sodium sulfate and concentrated under reduced pressure to afford a clear viscous oil that was immediately added to a biphasic mixture of diphyllin (1.090g, 2.87mmol) and TBAB (0.933g, 2.89mmol) in CHCl3 (100mL) and aqueous NaOH (0.1M, 100mL) at 40C. The mixture was maintained at 40C overnight. After cooling to room temperature, the layers were separated and the aqueous layer was extracted three times with CHCl3. The combined organic layers were washed with brine, dried with sodium sulfate, and concentrated under reduced pressure. Flash chromatography (silica gel, 0.3%?1% MeOH in CHCl3) afforded compound 8a (1.928g, 95%) as a white solid:

83-87-4 (3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate 10293747, aTetrahydropyrans compound, is more and more widely used in various fields.

Reference£º
Article; Woodard, John L.; Huntsman, Andrew C.; Patel, Pratiq A.; Chai, Hee-Byung; Kanagasabai, Ragu; Karmahapatra, Soumendrakrishna; Young, Alexandria N.; Ren, Yulin; Cole, Malcolm S.; Herrera, Denisse; Yalowich, Jack C.; Kinghorn, A. Douglas; Burdette, Joanna E.; Fuchs, James R.; Bioorganic and Medicinal Chemistry; vol. 26; 9; (2018); p. 2354 – 2364;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics

951127-25-6, tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15a (342 mg, 0.656 mmol) and Intermediate 1 (236 mg, 0.722 mmol) were dissolved in N, N-dimethylacetamide (5 mL) and stirred at room temperature for 0.5 hour, A solution of sodium tris (acetoxy) borohydride (375.3 mg, 1.771 mmoL) was added to the ice bath,Stir at room temperature for 2 hours. To the reaction solution was added concentrated aqueous ammonia (10 mL) and saturated sodium chloride solution (30 mL)And the mixture was stirred for 0.5 hour. The filtrate was extracted with dichloromethane (30 mL x 3). The filter cake was dissolved with the combined organic phase, dried over anhydrous sodium sulfate, filtered and dried by rotary separation. The residue was purified by silica gel column chromatography (Dichloromethane / methanol (v / v) = 30: 1 to 20: 1, a small amount of aqueous ammonia was added) to give a yellow solid as a yellow solid 15b (200 mg, yield 59%).

951127-25-6, The synthetic route of 951127-25-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics